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胡小蕾 副教授
发布时间:2017-03-16 浏览次数:

胡小蕾        E-Mail:xiaolei_hu@cqmu.edu.cn

重庆医科大学,检验医学院/临床检验诊断学教育部重点实验室

教育经历

2007/09-2012/07,四川大学,化学学院,博士学位(导师:冯小明院士)

2003/09-2007/09,四川大学,化学学院,学士学位

工作经历

2012/07-至今,重庆医科大学,检验医学院/临床检验诊断学教育部重点实验室,副教授

讲授课程

《生物传感器》、《医用有机化学实验》

主持科研项目及人才计划项目情况

1.重庆市教委科学技术研究项目,2016年,主持。

2.重庆市科委基础科学与前沿技术研究专项一般项目,2015年,主持。

3.国家自然基金委青年科学基金项目,2014年,主持。

4.重庆医科大学优秀青年学者项目,2013年,主持。

主要研究方向

通过设计、合成一系列小分子探针,应用不同的原理构建高灵敏度、特异性地定量、定性测定目标生物分子有效的分析检测体系。

发表SCI论文

1.Xiaolan Yang,Xiaolei Hu, Chunyan Chen, Gaobo Long, Jing Wu, Deng Tan, Yuanli Li,Yiran Feng, Jun Pu, Fei Liao. Comparison of the immobilization of 6His-taggedproteins on magnetic-submicron-particle functionalized with Ni2+-NTAand bis-sulfone. Nanosci NanotechnLett, 2015, 7(6):486-494.

2.Tianyu Huang,   Lili Lin,   Xiaolei Hu,   JianfengZheng,  Xiaohua Liua and   Xiaoming Feng* Kinetic resolution of 2,3-epoxy 3-arylketones viacatalytic asymmetric ring-opening with pyrazole derivatives.Chem. Commun., 2015, 51, 11374-11377.

3.Hongbo Liu#, Mei Yuan#, XiaolanYang#, Xiaolei Hu, Jizheng Dang, Yanling Xie, Jun Pu, Yuanli Li,Chang-Guo Zhan, Fei Liao*. Comparison of candidate pairs ofhydrolytic enzymes for spectrophotometric-dual-enzyme-simultaneous-assay. Anal Sci 2015, 31(5):421-427.

4.Yuanli Li#, Gaobo Long#, Xiaolan Yang#, Xiaolei Hu,Yiran Feng, Deng Tan, Yanling Xie, Jun Pu, Fei Liao*. Approximated maximumadsorption of His-tagged enzyme/mutants on Ni2+-NTA for comparisonof specific activities. Int J Biol Macromol2015; 74C: 211-217.

5.Ya Huang#, Yuanxiang Chen#,Xiaolan Yang#, Hua Zhao, Xiaolei Hu, Jun Pu, Juan Liao, Gaobo Long,Fei Liao*. Optimization of pH values to formulate the bi-reagent kit for serumuric acid assay. Biotechnol Appl Biochem 2015, 62(1):137-144.

6.Bangtian Xu#,Deng Tan#, Xiaolan Yang#, XiaoleiHu, Yanling Xie, Jialin Qin, ChunyanChen, Chenxiong He, Yuanli Li, Jun Pu, Fei Liao*.Fluorometric titration assayof affinity of tight-binding nonfluorescent inhibitor of glutathiones-transferase. J Fluoresc. 2015, 25(1):1-8.

7.Xiaolan Yang,Xiaolei Hu, Bangtian Xu, Xin Wang,Jialin Qin, Chenxiong He, Yanling Xie, Yuanli Li, Lin Liu, Fei Liao*.Fluorometrictitration approach for calibration of quantity of binding site of purifiedmonoclonal antibody recognizing epitope/hapten nonfluorescent at 340 nm.Anal Chem. 2014,86(12):5667-5672.

8.Yuanli Li#, Xiaolan Yang#, ChenxiongHe, Xiaolei Hu, Jun Pu, Lin Liu,Gaobo Long, Fei Liao*. Facile quantitative comparison of specific activities offusion-tagged enzyme/mutants in cell lysates via prediction of their maximumadsorption by anti-tag antibody immobilized in microplate wells. RSCAdvance.2014, 4(56): 29925-29932.

9.Chun Zhang#, Xiaolan Yang#, Ang Gao, Xiaolei Hu, Jun Pu, Hongbo Liu, JuanFeng, Juan Liao, Yuanli Li, Fei Liao*. Comparison of modification of abacterial uricase with N-hydroxysuccinimide esters of succinate and carbonateof monomethoxyl poly(ethylene glycol). Biotechnol Appl Biochem.2014, 61(6):683-690.

10.Hongbo Liu#, Xiaolan Yang#, Jizheng Dang, Lin Liu, Xiaolei Hu, Jun Pu, Gaobo Long and Fei Liao*.Two glycosidases aslabel enzymes for concurrent enzyme-linked-immunosorbent-assay of twocomponents via spectrophotometric-dual-enzymesimultaneous-assay in onesolution. Anal Methods. 2013, 5(10): 5969-5976.

11.Yi Zhang#, Xiaolan Yang#, Xiaolei Hu#, Miaomiao Liu, ChunyanChen, Yanling Xie, Jun Pu, Jing Wu, Gaobo Long, FeiLiao*.Resonant-Mie-scattering of aggregates of phosphomolybdate and papaverinefor measuring activities and screening inhibitors of cyclic nucleotidephosphodiesterase isozymes. Anal Chim Acta 2013, 804:215-220.

12.Chunyan Chen#, Miaomiao Liu#,Jing Wu#, Xiaolan Yang, Xiaolei Hu,Jun Pu, Gaobo Long, Yanling Xie, Hairong Jiang, Yonghua Yuan, Fei Liao*.Microplate-based method to screen inhibitors of isozymes of cyclic nucleotidephosphodiesterase fused to SUMO. J Enzyme Inhib Med Chem. 2014,29(6): 836-839.

13.Xiaolei Hu, Bo Gao,Yangyang Chu, Wei Li, Xiaohua Liu, Lili Lin, Xiaoming Feng*.Enantioselectivesynthesis of β-pyrazole-substituted alcohols through asymmetric ring openingreaction of meso-epoxides. Chem Eur J,2012, 18(12):3473-3477.

14.Yangyang Chu, Xiaohua Liu, Wei Li, Xiaolei Hu, Lili Lin, XiaomingFeng*.Asymmetric catalytic epoxidation of α,β-unsaturated carbonyl compoundswith hydrogen peroxide: Additive-free and wide substrate scope. ChemSci, 2012, 3(6):1996-2000.

15.Wei Li,Xiaohua Liu, Xiaoyu Hao, Xiaolei Hu, Yangyang Chu, Weidi Cao, Song Qin,Changwei Hu, Lili Lin,and Xiaoming Feng* “New Electrophilic Addition of α-Diazoesterswith Ketones for Enantioselective C-N Bond Formation” J. Am. Chem. Soc.2011, 133, 15268.

16.WeiLi, Jun Wang, Xiaolei Hu, Ke Shen,Wentao Wang, Yangyang Chu, Lili Lin, Xiaohua Liu, Xiaoming Feng* “Catalytic Asymmetric Roskamp Reaction ofα-Alkyl-α-diazoesters with Aromatic Aldehydes: Highly EnantioselectiveSynthesis of α-Alkyl-β-keto-Esters” J. Am. Chem. Soc.2010, 132, 8532.

17.Ke Shen,Xiaohua Liu, Ke Zheng, Wei Li, XiaoleiHu, Lili Lin, and Xiaoming Feng* “Catalytic Asymmetric Synthesis of3-(α-Hydroxy-β-carbonyl) Oxindoles by a ScIII-Catalyzed Direct Aldol-TypeReaction” Chem. Eur. J.2010, 16, 3736.

18.Yunfei Cai, Wentao Wang,Ke Shen, Jun Wang, Xiaolei Hu, LiliLin, Xiaohua Liu, Xiaoming Feng* “Highlyenantioselective α-chlorination of cyclic b-ketoesters catalyzed byN,N'-Dioxide using NCS as the chlorine source”Chem. Commun.,2010, 46, 1250.

19.WentaoWang, Ke Shen, Xiaolei Hu, Jun Wang,Xiaohua Liu, Xiaoming Feng* “HighlyEnantioselective Synthesis of α-Diazo-β-hydroxy Esters Using a BifunctionalTitanium Complex” Synlett.2009, 10, 1655.

20.Jun Wang, Wentao Wang,Wei Li, Xiaolei Hu, Ke Shen, ChengTan, Xiaohua Liu, Xiaoming Feng*“Asymmetric Cyanation of Aldehydes, Ketones,Aldimines, and Ketimines Catalyzed by a Versatile Catalyst Generated fromCinchona Alkaloid, Achiral Substituted 2,2’-Biphenol and Tetraisopropyl Titanate” Chem.Eur. J.2009, 15, 11642.

21.Xiaolei Hu, Jun Wang, Wei Li, Lili Lin, Xiaohua Liu, XiaomingFeng*. Cinchona alkaloid-derived quaternary ammonium salt combined with NaH: afacile catalyst system for the asymmetric trifluoromethylation of ketones. TetrahedLett, 2009, 50(30), 4378-4380.

22.JunWang, Xiaolei Hu, Jun Jiang, ShaohuaGou, Xiao Huang, Xiaohua Liu, Xiaoming Feng* “Asymmetric Activation of tropos 2,2’-Biphenol with Cinchonine Generates an EffectiveCatalyst for the Asymmetric Strecker Reaction of N-Tosyl-Protected Aldiminesand Ketoimines” Angew. Chem. Int. Ed.2007, 46, 8468. (Vip papaer)


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