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施 琼 教授
发布时间:2017-02-08 浏览次数:


施琼,女,医学博士,教授,硕士生导师。

Qiong Shi, Femal, M.D & Ph.D, Professor


1987-1992年本科就读于重庆医科大学临床医学系,获医学学士学位后留校任教至今。2002-2004于重庆医科大学攻读医学遗传学硕士学位,2004-2007于重庆医科大学攻读博士学位,获医学生物工程博士学位。2006.3-2007.3在北京国家蛋白质研究中心参与“国际人类肝脏蛋白质组计划”中蛋白质相互作用方面的研究工作。2009.3-2010.9在美国芝加哥大学医学中心骨科分子肿瘤研究室做访问学着,进行博士后研究工作。在美期间,主要从事BMP9诱导小鼠间充质干细胞成骨分化信号通路的研究

目前主要研究方向为microRNA在间充质干细胞定向成骨分化和肿瘤生理。作为负责人承担了三项国家自然科学基金:microRNA-30a和microRNA-30e调控Bub1基因影响小鼠早期胚胎发育的机制研究(NSFC 30872770)、microRNA的表观遗传学调控在BMP9诱导MSCs成骨分化中的机制研究(NSFC 31200971)、Lp(a) 调控 BMP-7 促进主动脉瓣膜钙化的机制研究(NSFC 81672103),以及重庆市科委、市教委等多项科研项目,并参与了多项国家级和省部级课题研究。获国家发明专利一项(共同专利权人)。以第一作者或通讯作者发表科研论文四十余篇,其中SCI收录十余篇。

近年发表的代表性论文:

1.Chu Chen,Zuchuan Tang, Qiling Song, Min Yang, QiongShi* and Yaguang Weng: Downregulated microRNA-23b promotesBMP9-mediated osteogenesis in C2C12 myoblast cells by targeting Runx2. MOLECULARMEDICINE REPORTS, 2015.December 1. (corresponding authors)

2.JingWang, Yaguang Weng, Minghao Zhang, Ya Li, Mengtian Fan, Yangliu Guo, YantingSun, Wang Li, Qiong Shi*:BMP9 inhibits the growth and migration of lung adenocarcinoma cells A549 inbone marrow stromal cells involved microenvironment by MAPK/ERK and NF-κBpathway. Oncology Reports, 2016 Jul;36(1):410-8.

3.QilingSong, Liang Zhong, Chu Chen, Zuchuan Tang, Hongxia Liu, Yiqin Zhou, Min Tang,Lan Zhou, Guowei Zuo, Jingyong Luo, Yan Zhang, Qiong Shi* and Yaguang Weng:miR-21synergizes with BMP9 in osteogenic differentiation by activating theBMP9/Smadsignaling pathway in murine multilineage cells. INTERNATIONAL JOURNAL OFMOLECULAR MEDICINE, 2015, September 30, published online. (corresponding authors)

4.RuyiZhang, Shujuan Yan, Jing Wang, Fang Deng, Ya ng liu Guo, Ya Li, Mengtian Fan,Qilin Song, Hongxia Liu, Yaguang Weng, QiongShi *: MiR-30a regulates the proliferation, migration, and invasionofhuman osteosarcoma by targeting Runx2. Tumor Biol, 2015, Sep 13, publishedonline.

5.RuyiZhang, Yaguang Weng, Baolin Li, Yingjiu Jiang, Shujuan Yan, Fang He, XiaoqingChen, Fang Deng, Jing Wang, Qiong Shi*: BMP9-induced osteogenic differentiation is partially inhibited by miR-30a inthe mesenchymal stem cell line C3H10T1/2. J Mol Hist, 2015, July 24.

6.GuoYe, Conghua Li, Xuerong Xiang, Chu Chen, Ruyi Zhang, Xia Yang, Xuesong Yu,Jinhua Wang, Lan Wang, Qiong Shi*, Yaguang Weng: Bone Morphogenetic Protein-9 Induces PDLSCs OsteogenicDifferentiation through the ERK and p38 Signal Pathways. Int. J. Med. Sci, 2014;11(10): 1065-1072. (corresponding authors)

7.HuiliBai, Yaguang Weng, Shunjie Bai, Yingjiu Jiang, Baolin Li, Fang He,Ruyi Zhang,Shujuan Yan, Fang Deng, Jing Wang andQiong Shi *:CCL5 secreted frombone marrow stromal cells stimulates the migration and invasion of Huh7hepatocellular carcinoma cells via the PI3K-Akt pathway.International Journal of Oncology , 2014 Jul;45: 333-343.

8.Jiye Zhang, YaguangWeng,  Xing Liu, Jinhua Wang, Wenwen Zhang, Stephanie H Kim, Hongyu Zhang,Ruidong Li, Yuhan Kong, Xiang Chen, Wei Shui, Ning Wang, Chen Zhao, NingningWu, Yunfeng He, Guoxin Nan, Xian Chen, Sheng Wen, Hongmei Zhang, Fang Deng,Lihua Wan, Hue H. Luu, Rex C. Haydon, Lewis L. Shi, Tong-Chuan He and Qiong Shi*: Endoplasmic reticulum(ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) isan important mediator of BMP9-regulated osteogenic differentiation ofmesenchymal stem cells. PLOS One,2013; 8(9) :1-9

9.Zilan Lv, Chuan Wang, Taixian Yuan, Yuehong Liu, Tao Song, Yueliang Liu, Chu Chen, Min Yang, Zuchuan Tang, QiongShi*, and Yaguang Weng*: Bone morphogenetic protein 9 regulates tumorgrowth of osteosarcoma cells through the Wnt/β-catenin pathway. OncologyReports, 2014 Feb;31(2):989-994. (corresponding authors)

10.MinLuo, YaguangWeng, Jian Tang, Min Hu, Qiang Liu, Fengbing Jiang, Dandan Yang ,Chen Liu, Xiaoqin Zhan, Peipei Song, Huili Bai, Baolin Li, Qiong Shi *: MicroRNA-450a-3pRepresses Cell Proliferation and Regulates Embryo Development by RegulatingBub1Expression in Mouse. PLoS ONE, 2012; 7(10):1-8

11.Chen Liu, Yaguang Weng,Taixian Yuan, Hong Zhang, Huili Bai, Baolin Li, Dandan Yang, Ruyi Zhang, FangHe, Shujuan Yan, Xiaoqin Zhan, QiongShi1*: CXCL12/CXCR4 Signal Axis Plays anImportant Role in Mediating Bone Morphogenetic Protein 9-induced osteogenicDifferentiation of Mesenchymal Stem Cells. Int J. Med. Sci, 2013;10 (9):1181-1192.

12.MinHu, Qingsong Liu, Peipei Song, Xiaoqin Zhan, Min Luo, Chen Liu,Dandan Yang, Yan Cai,Fan Zhang, Fengbing Jiang, Yan Zhang, Min Tang,Guowei Zuo, Lan Zhou,Jinyong Luo, Qiong Shi*and Yaguang Weng: Abnormal expression of the mitotic checkpointprotein BubR1 contributes to the anti-microtubule drug resistance of esophagealsquamous cell carcinoma cells. Oncology Reports, 2013; 29: 185-192. (corresponding authors)

13.Qiong Shi, MinHu, Min Luo, Qiang Liu, Fengbing Jiang, Yan Zhang, SujiaWang, Chen Yan, andYaguangWeng*:  Reduced expression ofMad2 and Bub1 proteins is associated withspontaneous Miscarriages. Molecular HumanReproduction, 2011; 17(1): 14–21.

14.Zilan Lv, Dandan Yang, Jie Li, Min Hu, Min Luo,Xiaoqin Zhan, Peipei Song, Chen Liu, Huili Bai, Baolin Li,Yang Yang, YingyingChen, Qiong Shi*, and YaguangWeng*: Bone morphogenetic protein 9 overexpression reduces osteosarcomacell migration and invasion. Molecules and Cell, 2013;36(2). (corresponding authors)

15.李亚,陈思成,王静,邓芳,孙燕婷,李汪,施琼*:肿瘤相关M2型巨噬细胞通过VEGFR3增强肺腺癌A549细胞迁移和侵袭。肿瘤,2016, 36(8):846-856.

16.邓芳,王静,范梦恬,郭杨柳,李亚,施琼*:过表达白细胞介素8促进乳腺癌BT549细胞迁移。细胞与分子免疫学杂志,2016, 32(5): 585-589.

17.王静,邓芳,李亚,范梦恬,郭杨柳,施琼*:过表达BMP9对人肺鳞癌细胞NCI-H520迁移和侵袭的影响。中国病理生理杂志,2015,31(11):1921-1927.

18.张汝益,何方,王静,邓芳,李琪英,施琼*:miR-30a抑制人骨肉瘤细胞143B的迁移侵袭和活力。基础医学与临床,2015,35(1): 12-16.

19.何方,张汝益,王静,邓芳,范梦恬,李亚,郭杨柳,施琼*:趋化因子受体CX3CR1表达沉默对人肝细胞癌Huh7细胞的作用及机制研究。肿瘤,

20.白慧丽,李宝林,何方,张汝益,严树涓,刘晨,杨丹丹,施琼*:骨髓基质细胞介导的微环境对人肝癌细胞株SMMC-7721的作用以及机制研究。中国病理生理杂志,2013,29(11):1921-1927.

21.李宝林,白慧丽,张汝益,严树涓,何方,杨丹丹,刘晨,施琼*:miR30a抑制BMP9诱导间充质干细胞C3H10T1/2的成骨分化。中国生物工程杂志,2013,33(11):14-20。

22.杨丹丹,刘晨,白慧丽,李宝林,何方,张汝益,施琼*:腺病毒介导的BMP9过表达抑制人骨肉瘤细胞系143B的增值与迁移。基础医学与临床,2013,33(9):1091-1096。

23.刘晨,杨丹丹,白慧丽,李宝林,何方,张汝益,严树涓,施琼*:SDF-1/CXCR4在BMP9介导C2C12细胞成骨分化过程中的作用研究。中国细胞生物学学报,2013;35(2)154-162。

24.蒋凤兵,闫文婷,朱勇,王斌,马艳妮,余佳,施琼*:EKLF转录激活miR-96在红系分化过程中表达。基础医学与临床,2012,32(4):369-374.

25.杨丹丹,刘晨,蒋凤兵,李宝林,白慧丽,施琼*:miR-450a对体外培养小鼠早期胚胎发育的影响。中国生物制品学杂志,2012,25(7):859-861.

26.刘晨,杨丹丹,蒋凤兵,白慧丽,李宝林,罗敏,湛晓琴,施琼*:MicroRNA-450a-3p通过抑制Bub1基因的表达调控小鼠细胞增殖和胚胎发育。中国病理生理杂志,2012;28(9):1651-1657。

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