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专职教师

谢国明 教授,博士生导师

2019年03月21日 00:00  点击:[]

谢国明,男,1966年出生,主任,三级教授,博士生导师。

Guoming Xie(1966.12~), Director, Professor level 3.

1994年讲师,2002年副教授,2009年教授;2003年硕士生导师,2015年博士生导师,2017年博士后合作导师。

分子生物学即时检验与生物传感课题组负责人,国家精品课程《临床检验仪器学》主讲教师,曾任医学检验系仪器室副主任,临床检验诊断学实验教学中心副主任,临床检验诊断学教育部重点实验室副主任,现任检验医学院临床检验仪器学教研室主任。

联系信息:

重庆市渝中区医学院路1号,重庆医科大学检验医学院临床检验诊断学教育部重点实验室,400016

Tel,+86-23-68485240; E-mail, guomingxie@cqmu.edu.cn; 504524429@qq.com

http://yjsy.cqmu.edu.cn:8080/gmis/xkjsb/yjsdsfc.aspx?id=100976

http://www.researchgate.net/profile/Guoming_Xie

学习(进修)与工作经历

1985.9~1989.7,重庆大学电子工程系,生物医学电子学士;

1989.7~1994.8,重庆医科大学医学检验系临床检验仪器学教研室;

1994.9~1997.7,重庆大学生物工程学院,生物医学工程与仪器硕士;

1997.8~2012.11,重庆医科大学检验医学院/临床检验诊断学教育部重点实验室;

2012.12~2013.6,Department of ECE,University of Nevada, Las Vegas, USA, Visiting Scholar (Professor, Ying-TaoJiang);

2013.7~2013.11,Department ofChemistry, University of Illinois at Urbana-Champaign, USA, Visiting Scholar(Professor, Yi Lu);

2013.12~至今,重庆医科大学检验医学院临床检验仪器学教研室。

荣誉和奖励

2013年,重庆市高等教育教学成果三等奖

2012年,重庆医科大学优秀研究生导师

2010年,中国大学生“挑战杯”竞赛重庆市金奖及全国铜奖指导教师

1993年,四川省优秀教学成果二等奖。

学术兼职

《分析仪器》杂志编委,中国分析测试协会标记免疫分析专业委员会委员,重庆国家生物产业基地公共实验中心专家,中国体外诊断产业技术创新联盟专家。

Theranostics,Biosensors and Bioelectronics, Colloids and Surfaces B: Biointerfaces, Sensors& Actuators B: Chemical等杂志审稿人。

研究方向

1.纳米生物传感研究,紧密结合重大疾病,流行疾病快速与微创或无创检测迫切需求,将现代分子诊断学、免疫学、生物电化学、光学、生物信息学等多学科交叉融合,构建满足检验医学快速检测生物传感新方法与技术。对建立组织、细胞及分子水平检测新方法与技术具有重要的科学意义;

2.微流控芯片与检测系统研究,设计与构制多功能微阵列芯片、分子探针、细胞传感器、DNA传感器。在信号处理、软件设计及仪器小型化集成形成特色。在精准医疗和即时检验领域具有重要的意义和实用价值。

主持或参与的科研项目

2017-2020年,国家自然科学基金“基于UDG介导PCR、磁性纳米富集和链置换反应的SNPs准确快速检测方法”,编号81672112(排名第1);

2014-2017年,重庆市渝中区科委项目“基于新型“功能核酸-酶”缀合物的即时检验方法研究”, 编号20140108(排名第1);

2012-2015年,国家自然科学基金“快速检测细菌耐药的超灵敏生物传感阵列新方法”,编号81171415(排名第1);

2010-2013年,重庆市自然科学基金项目“弓形虫循环抗原定量即时检测的电化学免疫生物传感新方法研究”,编号CSTC2010BB5356(排名第1);

2009-2010年,重庆市科技攻关项目“基于电化学生物传感器的血酒精即时检测系统”, 编号CSTC2009AC5145(排名第2);

2008-2010年,国家自然科学基金“底层图像挖掘技术及其在法医学中的应用” ,编号30772459(排名第2);

2008-2010年,国家自然科学基金“基于积分球增强共振光散射检测技术的均相亲合分析方法”,编号30700775(排名第2);

2008-2010年,重庆市自然科学基金项目“快速、非标记溶致液晶免疫传感器研究”, 编号CSTC2008BB5395(排名第2);

2006-2008年,重庆市自然科学基金项目“联合定量检测AMI生化标志物生物传感阵列方法研究”, 编号CSTC2006BB5272(排名第1)。

2010年以来作为通讯作者发表的论文

2018年

1.Sitian Tang, Huawei Shen, Yixiong Hao, Zhenglan Huang, Yiyi Tao, Yang Peng, YongcanGuo, Guoming Xie, Wenli Feng. A novel cytosensor based on Pt@ Ag nanoflowersand AuNPs/Acetylene black for ultrasensitive and highly specific detection ofCirculating Tumor Cells[J]. Biosensors and Bioelectronics, 2018.

2. YuxiaLi, Guoming Xie, Juhui Qiu, Dandan Zhou, Dan Gou, Yiyi Tao, Yi Li,Hui Chen.A new biosensor based on the recognition of phages andthe signal amplification of organic-inorganic hybrid nanoflowers fordiscriminating and quantitating live pathogenic bacteria in urine[J]. Sensors andActuators B: Chemical, 2018, 258: 803-812.

2017年

1. YiyiTao, Dan Yin, Mingchao Jin, Jie Fang, Tao Dai, Yi Li, Yuxia Li, Qinli Pu,Guoming Xie.Double-loop hairpin probe and doxorubicin-loadedgold nanoparticles for the ultrasensitive electrochemical sensing ofmicroRNA[J]. Biosensors and Bioelectronics, 2017, 96: 99-105.

2. QinliPu, Junlong Li, Juhui Qiu, Xuanhua Yang, Yi Li, Dan Yin, Xinyuan Zhang, YiyiTao, Shangchun Sheng, Guoming Xie.Universal ratiometricelectrochemical biosensing platform based on mesoporous platinum nanocompositeand nicking endonuclease assisted DNA walking strategy[J]. Biosensors andBioelectronics, 2017, 94: 719-727.

3.Junlong Li, Kexin Sun, Zhongping Chen, Jifei Shi, Dandan Zhou, Guoming Xie. Afluorescence biosensor for VEGF detection based on DNA assembly structureswitching and isothermal amplification[J]. Biosensors and Bioelectronics, 2017,89: 964-969.

4.Shulian Bai, Ting Wang, Zhang Zhang, Shangchun Sheng, Wen Yu, Guoming Xie. Anovel colorimetric biosensor for detecting target DNA and human alpha thrombinbased on associative toehold activation concatemer induced catalyzed hairpinassembly amplification[J]. Sensors and Actuators B: Chemical, 2017, 239:447-454.

2016年

1.Junlong Li, Zhongping Chen, Yu Xiang, Lili Zhou, Ting Wang, Zhang Zhang,KexinSun, Dan Yin, Yi Li, Guoming Xie.An electrochemicalbiosensor for double-stranded Wnt7B gene detection based on enzymaticisothermal amplification[J]. Biosensors and Bioelectronics, 2016, 86: 75-82.

2.Huawei Shen, Juan Yang, Zhongping Chen, Xueping Chen, Li Wang, Jing Hu, FeihuJi, Guoming Xie, Wenli Feng. A novel label-free and reusable electrochemicalcytosensor for highly sensitive detection and specific collection of CTCs[J].Biosensors and Bioelectronics, 2016, 81: 495-502.

3. ZhangZhang, Junlong Li, Juan Yao, Ting Wang, Dan Yin, Yu xiang, Zhongping Chen,Guoming Xie.Energy driven cascade recognition for selectivedetection of nucleic acids with high discrimination factor at roomtemperature[J]. Biosensors and Bioelectronics, 2016, 79: 488-494.

4. TingWang, Lili Zhou, Shulian Bai, Zhang Zhang, Junlong Li,Xiaoying Jing, GuomingXie. Ultraspecific electrochemical DNA biosensor by coupling spontaneouscascade DNA branch migration and dual-signaling sensing strategy[J]. Biosensorsand Bioelectronics, 2016, 78: 464-470.

5. JuanYang, Huawei Shen, Xing Zhang, Yiyi Tao, Hua Xiang, Guoming Xie. A novelplatform for high sensitivity determination of PbP2a based on goldnanoparticles composited graphitized mesoporous carbon and doxorubicin loadedhollow gold nanospheres[J]. Biosensors and Bioelectronics, 2016, 77: 1119-1125.

2015年

1. ZhangZhang, Shangchun Sheng, Xianqing Cao, Yiyan Li, Juan Yao, Ting Wang, GuomingXie. Proximity-based electrochemical biosensor for highly sensitivedetermination of methyltransferase activity using gold nanoparticle-basedcooperative signal amplification[J]. Microchimica Acta, 2015, 182(13-14):2329-2336.

2. Lingzhi Liu, Chao Song, Zhang Zhang, JuanYang, Lili Zhou,Xing Zhang, GuomingXie. Ultrasensitive electrochemical detection of microRNA-21combining layered nanostructure of oxidized single-walled carbon nanotubes andnanodiamonds by hybridization chain reaction. Biosensors and Bioelectronics,2015 ,70: 351-357.

3. TingWang, Zhang Zhang, Yiyan Li, Guoming Xie. Amplified electrochemical detectionof mecA gene in methicillin-resistant Staphylococcus aureus based on targetrecycling amplification and isothermal strand-displacement polymerizationreaction. Sensors and Actuators B: Chemical, 2015.221:148-154.

4.Lingzhi Liu, Shuting Jiang, Li Wang, Zhang Zhang, Guoming Xie. Direct detectionof microRNA-126 at a femtomolar level using a glassy carbon electrode modifiedwith chitosan, grapheme sheets, and a poly(amidoamine) denddrimer compositewith gold and silver nanoclusters. Microchim Acta, 2015, 182(1-2):77-84.

2014年

5.XiaoyingJing, Xianqing Cao, Li Wang, Tian Lan, Yiyan Li, Guoming Xie. DNA-AuNPs basedsignal amplification for highly sensitive detection of DNA methylation,methyltransferase activity and inhibitor screening. Biosensors andBioelectronics, 2014, 58:40-47.

6.RenniDeng, Li Wang, Guangzhao Yi, Erhui Hua, Guoming Xie. Target-induced aptarmerrelease strategy based on electrochemical detection of staphylococcalenterotoxin B using GNPs-ZrO2-Chits film. Colloids and Surfaces B:Biointerfaces,2014, 120:1-7.

7.LiWang, Erhui Hua, Mo Liang, Cuixia Ma, Zhangling Liu, Shangchun Sheng, Min Liu,Guoming Xie, Wenli Feng(*). Graphene sheets, polyaniline and AuNPs based DNAsensor for electrochemical detection of BCR/ABL fusion gene with functionalhairpin probe. Biosensors and Bioelectronics, 2014, 51:201-207.

8.MinLiu, Hua Xiang, Erhui Hua, Li Wang, Xiaoying Jing, Xianqing Cao, ShangchunSheng, Guoming Xie. Ultrasensitive electrochemical biosensor for the detectionof the mecA gene sequence in methicillin resistant strains of staphylococcusaureus employing gold nanoparticles. Analytical Letters, 2014,47(4):579-591.

2013年

9.CuixiaMa, Mo Liang, Li Wang, Hua Xiang, Yingtao Jiang, Yiyan Li, Guoming Xie.MultisHRP-DNA-coated CMWNTs as signal labels for an ultrasensitive hepatitis Cvirus core antigen electrochemical immunosensor. Biosensors and Bioelectronics,2013, 47:467-474.

10.ErhuiHua, Li Wang, Xiaoying Jing, Changtao Chen, Guoming Xie. One-step fabricationof integrated disposable biosensor based on ADH/NAD/meldola's blue/graphitizedmesoporous carbons/chitosan nanobiocomposite for ethanol detection. Talanta,2013, 111:163-169.

11.MoLiang, Li Wang, Cuixia Ma, Mingjun Zhang, Guoming Xie. Sandwich immunoassay forhepatitis C virus non-structural 5A protein using a glassy carbon electrodemodified with an Au-MoO3/Chitosan nanocomposite. Analytical Letters, 2013,46(8):1241-1254.

12.ShenfengLi(#), Li Wang(#), Yajuan Li, Xiaoying Zhu, Liang Zhong, Lingsong Lu, WeiZhang, Bei Liu, Guoming Xie, Wenli Feng(*). Electrochemical determination ofBCR/ABL fusion gene based on in situ synthesized gold nanoparticles and ceriumdioxide. Colloids and Surfaces B: Biointerfaces, 2013, 112:344-349.

13.ShutingJiang, Erhui Hua, Mo Liang, Bei Liu, Guoming Xie. A novel immunosensor fordetecting toxoplasma gondii-specific IgM based on goldmag nanoparticles andgraphene sheets. Colloids and Surfaces B: Biointerfaces, 2013, 101:481-486.

14.赵朝辉,王力,甘先云,朱昌安,刘成桂,郑军,谢国明.基于微机械电子系统的电化学电极阵列的研制。分析化学,2013,41(4):621-626.

2012年

15.LingsongLu, Bei Liu, Zhaohui Zhao, Cuixia Ma, Peng Luo, Chenggui Liu, Guoming Xie.Ultrasensitive electrochemical immunosensor for HE4 based on rolling circleamplification. Biosensors and bioelectronics, 2012, 33(1):216-221.

16.QizhiDiao, Yuan Li, Mi Zhou, Guoming Xie. A new immunosensor for serummyeloperoxidase based on self-assembly of multi-walled carbon nanotubes/thionine/gold nanoparticle-chitosan. Advanced Materials Research, 2012,343-344:1207- (EI)

17.WeiZhang, Guoming Xie(*), Shenfeng Li, Lingsong Lu, Bei Liu. Au/CeO2-chitosancomposite film for hydrogen peroxide sensing. Applied Surface Science, 2012,258(20):8222-8227.

18.蒋姝婷,陈中平,刁奇智,盛尚春,谢国明,张名均,徐华建。基于石墨烯及CeO2-Au 的一次性弓形虫IgM抗体免疫传感器。化学学报,2012,70(19):2085-2090。

19.BeiLiu, Lingsong Lu, Erhui Hua, Shuting Jiang, Guoming Xie. Detection of the humanprostate-specific antigen using an aptasensor with gold nanoparticlesencapsulated by graphitized mesoporous carbon. Microchimica Acta, 2012,178(1-2):163-170.

2011年

20.BeiLiu, Lingsong Lu, Qiong Li, Guoming Xie. A disposable electrochemicalimmunosensor for myeloperoxidase based on a indium tin oxide electrode modifiedwith a ionic liquid composite film composed of gold nanoparticles,poly(o-phenylenediamine) and carbon nanotubes. Microchim Acta, 2011,173(3-4):513-520.

21.LingsongLu, Bei Liu, Shengfen Li, Wei Zhang, Guoming Xie. Improved electrochemicalimmunosensor for myeloperoxidase in human serum based on nanogold/ceriumdioxide-BMIMPF6/L-Cysteine composite film. Colloids and Surfaces B:Biointerfaces, 2011, 86(2):339-344.

22.ShenghangZhen, Yan Wang, Chenggui Liu, Guoming Xie. A novel microassy for measuringblood alcohol concentration using the disposable biosensor strip. ForensicScience International, 2011, 207(1-3):177-182.

23.BeiLiu, Lingsong Lu, Chenggui Liu, Guoming Xie. Immunosensor for myeloperoxidasebased on PoPD-MWCNTs-ionic liquid/nanogold modified Au electrode. Acta ChimicaSinica, 2011, 69(4):438-444.

2010年

24.LingsongLu, Bei Liu, Chenggui Liu, Guoming Xie. Amperometrc immunosensor formyeloperoxidase in human serum based on a multi-wall carbon nanotube-ionicliquid-cerium dioxide film-modified electrode. Bulletin of the Korean ChemicalSociety, 2010, 31(11):3259-3264.

25.甄生航,郑军,邹超世,王艳,朱洋,邓世雄,谢国明,王箭. 基于多壁碳纳米管的三电极血乙醇生物传感器的研究.分析化学,2010,38(3):389-392.

26.JunZheng, Guoming Xie, Changtao Chen. An-amylase biosensor with1,1-dimethyl-3-(2-amino-1-hydroxyethyl) ferrocene as an electron transfermediator. 4nd International Conference on Bioinformatics and BiomedicalEngineering, iCBBE, 2010, pp344, Chengdu, 04.18-20 (ISTP).


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