丁敏,教授,博士生导师,重庆市色谱学会副理事长
联系信息:
重庆医科大学检验医学院/临床检验诊断学教育部重点实验室,400016
Email:dingmin@cqmu.edu.cn, Tel: 13808361903
学习(工作)经历:
1984年毕业于成都科技大学化学系(本科),
1988-1991年在重庆医科大学攻读药物分析硕士,获医学硕士学位。
2004年7月-12月在日本岛根大学医学部中心实验室研修。
获2003年首批重庆市优秀中青年骨干教师资助,第一批重庆高校创新团队临床检验诊断学创新团队成员。
从1984年-至今在重庆医科大学从事生物分析化学的教学和科研工作,主要从事生物活性物质和药物的分析方法的研究,尤其是对HPLC、MS的分析方法的研究。
主持国家自然科学基金”胆汁酸代谢物轮廓分析用于妊娠肝内胆汁淤积症的诊断和分度”(No: 200475069); 参加自然科学基金“基因修饰的DC细胞抗HBV研究”项目(No:39970673);主持“尿硫酸化胆汁酸代谢轮廓分析用于妊娠肝内胆汁淤积症诊断和分度”,高等学校博导基金联合资助课题(20115503110013),主持和参与市级和校级多项课题。
在Lancet Gastroenterol Hepatol,Analyst,Clinica Chimica Acta、分析化学、中华医学检验杂志等杂志发表论文60余篇,发明专利5项,主、参编6本教材。
代表性学术成果:
1.Can Luo#, Xiaoqing Zhang#, Yifan He, Hong Chen, Manran Liu, Haoran Wang,Lingfeng Tang, Gang Tu* , Min Ding* A pseudo-targeted metabolomics study based on serum bile acids profiling for the differential diagnosis of benign and malignant breast lesions.Steroids, 2021,175:108914
2.Caroline Ovadia*, Jenna Sajous*, Paul T Seed, Kajol Patel, Nicholas J Williamson, George Attilakos, Francesco Azzaroli, Yannick Bacq, Linoy Batsry,Kelsey Broom, Romana Brun-Furrer, Laura Bull, Jenny Chambers, Yue Cui,Min Ding, Peter H Dixon, Maria C Estiú, Fergus W Gardiner,Victoria Geenes, Monika Grymowicz, Berrin Günaydin, William M Hague, Christian Haslinger, Yayi Hu, Ugo Indraccolo, Alexander Juusela,Stefan C Kane, Ayse Kebapcilar, Levent Kebapcilar, Katherine Kohari, Jūratė Kondrackienė, Maria P H Koster, Richard H Lee, Xiaohua Liu,Anna Locatelli, Rocio I R Macias, Riza Madazli, Agata Majewska, Kasia Maksym, Jessica A Marathe, Adam Morton, Martijn A Oudijk,Deniz Öztekin, Michael J Peek, Andrew H Shennan, Rachel M Tribe, Valeria Tripodi, Naciye Türk Özterlemez, Tharni Vasavan, L F Audris Wong,Yoav Yinon, Qianwen Zhang, Keren Zloto, Hanns-Ulrich Marschall, Jim Thornton, Lucy C Chappell, Catherine Williamson.Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis.Lancet Gastroenterol Hepatol, 2021, 6: 547–558
3.Haoran Wang#, Xiaoqing Zhang#, Qianna Zhen, Wenbi Zou, Hong Chen, Can Luo, Min Ding*. Detection of spot urinary free metanephrines and 3-methoxytyramine with internal reference correction for the diagnosis ofpheochromocytomas and paragangliomas, Journal of Chromatography B, 2020, 1156:122306
4.Xiao Chen, Xiaoqing Zhang, Biao Xu, Yue Cui, Yifan He, Ting Yang, Yong Shao,Min Ding, The urinary bile acid profiling analysis of asymptomatic hypercholanemiaof pregnancy: A pseudo-targeted metabolomics study. Clinica Chimica Acta 497 (2019) 67–75
5.Wenjing Lyu#, Xiaoqing Zhang#, Zhong Zhang, Xiao Chen, Ying Zhou, Hong Chen, Haoran Wang, Min Ding*. A simple and sensitive electrochemical method for the determination of capsaicinoids in chilli peppers. Sensors & Actuators: B. Chemical, 2019, 288: 65-70.
6.Yue Cui, Biao Xu, Xiaoqing Zhang, Yifan He, Yong Shao, Min Ding*, Diagnostic and therapeutic pro?les of serum bile acids in women with intrahepatic cholestasis of pregnancy-a pseudo-targeted metabolomics study.Clinica Chimica Acta, 483 (2018) 135–141
7.Gang Tian#, Min Ding#, Biao Xu, Yifan He, Wenjing Lyu, Mingchao Jin, Xiaoqing Zhang*. A novel electrochemical biosensor for ultrasensitive detection of serum total bile acids based on enzymatic reaction combined with the double oxidation circular amplification strategy. Biosensors & Bioelectronics, 2018, 118: 31-35.
8.Ming Zuo, Qianna Zhen, Xiaoqing Zhang, Wenbi Zou, Xiangchun Yang, Gang Tian,Zhenghu Shi, Qifu Li, Min Ding*..High specificity of spot urinary free metanephrines in diagnosis and prognosis of pheochromocytomas and paragangliomas by HPLC with electrochemical detection. Clinica Chimica Acta, 478 (2018) 82–89
9.Xiaoqing Zhang, Mingsong Zhu, Biao Xu, Yue Cui, Gang Tian, Zhenghu Shi, Min Ding*.Indirect electrochemical detection for total bile acids in human serum. Biosensors and Bioelectronics,2016, 85, 563-567
10. Mingchao Jin#, Xiaoqing Zhang#, QianNa Zhen, YiFan He, Xiao Chen, Wenjing Lyu, Runchuan Han, Min Ding*. An electrochemical sensor for indole in plasma based on MWCNTs-chitosan modified screen-printed carbon electrode. Biosensors & Bioelectronics, 2017, 98: 392
11. Gang Tian, Xiao-Qing Zhang, Ming-Song Zhu, Zhong Zhang, Zheng-Hu Shi, Min Ding. Quantification of ethanol in plasma by electrochemical detection with an unmodified screen printed carbon electrode. Scientific Reports, | 6:23569 | DOI: 10.1038/srep23569
12. Li Ma, Xiao-Qing Zhang, Da-Xue Zhou, Yue Cui, Lin-Lin Deng, Ting Yang, Yong Shao,Min Ding.Feasibility of urinary microRNA profiling detection in intrahepatic cholestasis of pregnancy and its potential as a non-invasive biomarker.Scientific Reports, |6:31535 | DOI: 10.1038/srep31535
13. Jieying Gao, Biao Xub, Xiaoqing Zhang , Yue Cui , Linlin Deng , Zhenghu Shi, Yong Shao, Min Ding*. Association between serum bile acid profiles and gestational diabetes mellitus: A targeted metabolomics study. Clinica Chimica Acta. 2016, 459, 63-72
14. Xiaoqing Zhang, Mingsong Zhu, Biao Xu, Yue Cui, Gang Tian, Zhenghu Shi, Min Ding*. Indirect electrochemical detection for total bile acids in human serum. Biosensors and Bioelectronics,2016, 85, 563-567
15. Jieying Gao, Jian Wang, Ming Zuo, Li Ma, Yue Cui, Ting Yang, Min Din g*. A highly sensitive method for simultaneous determination of the quaternary ammonium pesticides chlormequat and mepiquat in pears and potatoes by modified QuEChERS-high performance liquid chromatography-tandem mass spectrometry. RSC Adv, 2015, 5, 5895-903
16. 丁敏,罗娟,张晓清,朱明松,崔悦,左明. 血清总胆汁酸检测试剂盒及其使用方法,中国,专利号,ZL201310659472.3,授权日,2015.12.30
17. 张晓清,金明超,丁敏,史争虎,何一帆,邹文毕.一种快速检测血浆吲哚的电化学传感器,中国,专利号,ZL201710280262.1,授权日,2019.07.05
18. 丁敏,吕文静,张晓清,田刚,金明超,陈霄. 一种高灵敏的血清总胆汁酸电化学检测方法,中国,专利号,ZL201710957789.3,授权日,2019.07.30
19. 丁敏,邹文毕,甑乾娜,张晓清,吕文静,陈霄,韩润川. 嗜铬细胞瘤诊断试剂盒及其使用方法,中国,专利号,ZL201710716931.5,授权日,2020.08.28
20. 张晓清,周莹,丁敏,吕文静,陈霄,韩润川. 一种辣椒中辣椒素的检测方法,中国,专利号,ZL201811257608.7,授权日,2021.04.09