罗进勇,1974年出生,医学博士,教授,博士生导师。
联系信息
重庆医科大学,检验医学院/临床检验诊断学教育部重点实验室,400016
联系方式:手机13637738426;E-mail, luojinyong888@hotmail.com
教育经历
1994.9-1999.7重庆医科大学医学检验系临床检验诊断学学士
1999.9-2002.7重庆医科大学医学检验系临床检验诊断学硕士
2005.9-2008.7重庆医科大学医学检验系临床检验诊断学博士
2006.4-2008.3美国芝加哥大学医学中心分子肿瘤实验室博士后研究助理
工作经历
2002.7-2004.7重庆医科大学医学检验系助教
2004.7-2009.7重庆医科大学医学检验系讲师
2009.7-2014.7重庆医科大学医学检验系副教授,硕士研究生导师
2014.7-2019.9 重庆医科大学检验医学院教授硕士研究生导师
2019.9-至今重庆医科大学检验医学院教授博士研究生导师
学术兼职
国家自然科学基金委员会生命科学部和医学部一审专家、重庆市科委自然科学基金评审专家、四川省自然科学基金评审专家、广西自然科学基金评审专家、天津市自然科学基金评审专家。
J Cell Mol Med、Curr Pharm Design、Archives of Oral Biology、Stem Cells International、Advances in Medical Sciences、Genes & Diseases和Aging-US审稿人。
《生物化学与生物物理进展》、《中国生物化学与分子生物学报》、《遗传》、《中国组织工程研究》、《重庆医学》杂志审稿专家
研究方向
分子肿瘤
间充质干细胞定向成骨及成脂分化机理
基因治疗载体
科研项目
重庆医科大学未来医学青年创新团队支持计划:以BMP9为核心的骨组织工程(项目号W0086,2022.1-2023.1,50万),负责人。
国家自然科学基金面上项目:Hedgehog信号途径调控BMP9诱导的间充质干细胞成骨分化(项目号81874001,2019.1-2022.12,57万),负责人。
国家自然科学基金面上项目:BMP9/PI3K/AKT信号途径调控间充质干细胞成骨分化(项目号81272006,2013.1-2016.12,68万),负责人。
国家自然科学基金面上项目:BMP9-MAPK信号途径调控间充质干细胞成骨分化(项目号31071304,2011.1-2013.12,34万),负责人。
国家自然科学基金青年基金项目:系统分析TGFβ受体在BMP9诱导成骨中的作用(项目号30800658,2008.1-2010.12,20万),负责人。
重庆市科委一般项目:Hedgehog信号途径调控BMP9诱导的间充质干细胞成骨分化(项目号cstc2017jcyjAX0196,2017.8-2020.8,5万),负责人。
重庆市科委一般项目:BMP9活化PI3K/AKT信号途径调控间充质干细胞定向成骨分化(项目号cstc2013jcyjA10061,2013.7-2016.7),5万,负责人。
重庆市科委归国人员直通车项目:鉴定分析与BMP9诱导成骨有关的TGFβ受体(项目号2009BB50602008-2010,2008.6-2011.6,3万),负责人。
重庆市教委项目雏鹰计划:SHH增强BMP9诱导的间充质干细胞成骨分化,(2015.12-2016.12,2万),负责人。
重庆市“口腔疾病与生物医学重庆市重点实验室”开放基金:骨形态发生蛋白9(BMP9)经PI3K/AKT信号途径调控间充质干细胞成骨分化(项目号ODBS-2014-002 2015.1-2016.12,20万),负责人。
研究论文
1.Jingtao Xu, Xiaoxuan Wang, Lijuan Luo, Haichao Xia, Qiuping Lu, Yanran Huang, Yuping Wang, Jun Zhang, Habu Jiwa, Runhan Zhao, Chuang Xiong,Jinyong Luo, Xiaoji Luo. Neferine inhibits the growth of human osteosarcoma cells through activating P38/JNK and suppressing Wnt/β-catenin signaling pathway. Journal of Functional Foods. 2022;87:105262 (Accepted. https://www.sciencedirect.com/science/article/pii/S1756464622003322,共同通讯作者)
2.Huakun Huang, Qiuping Lu, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo,Jinyong Luo. Andrographolide inhibits the growth of human osteosarcoma cells by suppressing Wnt/β-catenin, PI3K/AKT and NF-κB signaling pathways. Chem Biol Interact. 2022;365:110068. doi: 10.1016/j.cbi.2022.110068. Online ahead of print.(通讯作者)
3.Caihong Ye, Mengqi Wei, Huakun Huang, Yuping Wang, Lulu Zhang, Chunmei Yang, Yanran Huang,Jinyong Luo. Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways. Biol Chem. 202210;403(10):929-943.
4.Mengqi Wei, CaihongYe, Huakun Huang, ChunmeiYang, Lulu Zhang, Yanran Huang, Yuping Wang, Xiaoji Luo,Jinyong Luo. Acacetin inhibits the tumor growth of human osteosarcoma cells through regulating Wnt/β-catenin and JNK signaling pathways. Journal of Functional Foods. 2022;93:105103 (Accepted.https://www.sciencedirect.com/science/article/pii/S1756464622001736,通讯作者)
5.Yuping Wang, Jin Chen, Yanran Huang, Shengdong Yang, Tao Tan, Nan Wang, Jun Zhang, Caihong Ye, Mengqi Wei,Jinyong Luo, Xiaoji Luo. Schisandrin B suppresses osteosarcoma lung metastasis in vivo by inhibiting the activation of the Wnt/β‑catenin and PI3K/Akt signaling pathways. Oncol Rep. 2022;47(3):50. doi: 10.3892/or.2022.8261. Epub 2022 Jan 14.(共同通讯作者)
6.Lulu Zhang, Chunmei Yang, Yanran Huang, Huakun Huang, Xiaohui Yuan,Ping Zhang,Caihong Ye, Mengqi Wei,Yuping Wang, Xiaoji Luo,Jinyong Luo. Cardamonin inhibits the growth of human osteosarcoma cells through activating P38 and JNK signaling pathway. Biomedicine & Pharmacotherapy. 2021;134:111155. doi: 10.1016/j.biopha.2020.111155. Epub 2020 Dec.(通讯作者)
7.Ping Zhang, Xiaohui Yuan, Tingting Yu,Huakun Huang, Chunmei Yang, Lulu Zhang, Shengdong Yang, Xiaoji Luo,Jinyong Luo. Lycorine inhibited cell growth, migration, invasion and mainly exerted in vitro cytostatic effects in human colorectal cancer possibly through activating ROS/p38 and AKT pathways. Oncology Reports. 45(4):1. doi: 10.3892/or.2021.7970. Epub 2021 Mar 2.(通讯作者)
8.Yanran Huang, Jin Chen, Shengdong Yang, Tao Tan, Nan Wang, Yuping Wang, Lulu Zhang, Chunmei Yang, Huakun Huang,Jinyong Luo, Xiaoji Luo. Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways. Drug Des Devel Ther. 2020;14:4625-4637. doi:10.2147/DDDT.S277160. eCollection 2020.(通讯作者)
9.Xiao-Hui Yuan, Ping Zhang, Ting-Ting Yu, Hua-Kun Huang, Lu-Lu Zhang, Chun-Mei Yang, Tao Tan, Sheng-Dong Yang, Xiao-Ji Luo,Jin-Yong Luo. Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/β-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway. Am J Transl Res. 2020;12(9): 5381–5398.(通讯作者)
10.Chunmei Yang, Lulu Zhang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yanran Huang, Xiaoji Luo,Jinyong Luo. Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways. Genes & Diseases. 2020. https://doi.org/10.1016/j.gendis.2020.07.014(通讯作者,Accepted,Published online at: https://doi.org/10.1016/j.gendis.2020.07.014)
11.Shengdong Yang, Jin Chen, Tao Tan, Nan Wang, Yanran Huang, Yuping Wang, Xiaohui Yuan, Ping Zhang,Jinyong Luo, Xiaoji Luo. Evodiamine Exerts Anticancer Effects Against 143B and MG63 Cells Through the Wnt/β-Catenin Signaling Pathway. Cancer Manag Res. 2020;12:2875-2888.(共同通讯作者)
12.Tan T, Chen J, Hu Y, Wang N, Chen Y, Yu T, Lin D, Yang S,Luo J, Luo X. Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/β-catenin signaling. Onco Targets Ther. 2019;12:5111-5122.(共同通讯作者)
13.Liu X, Ji C, Xu L, Yu T, Dong C,Luo J.Hmox1 promotes osteogenic differentiation at the expense of reduced adipogenic differentiation induced by BMP9 in C3H10T1/2 cells.2018;119(7):5503-5516. doi: 10.1002/jcb.26714. Epub 2018 Mar 25.(通讯作者)
14.Wang Y, Feng Q, Ji C, Liu X, Li L,Luo J. RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells. Int J Mol Med. 2017;40(6):1991-1999.(通讯作者)
15.Ji C, Liu X, Xu L, Yu T, Dong C,Luo J.Runx1 plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12 and MEFs. Int J Mol Sci. 2017;18(7). pii: E1348. doi: 10.3390/ijms18071348.(通讯作者)
16.罗进勇.骨形态发生蛋白9促成骨的分子机制.重庆医学. 2016;45(9):1153-1155.(专家述评)
17.Zhang H, Li L, Dong Q, Wang Y, Feng Q, Ou X, Zhou P, He T,Luo J. Activation of PKA/CREB Signaling is involved in BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells. Cell Physiol Biochem. 2015;37(2):548-562.(通讯作者)
18.Li L, Dong Q, Wang Y, Feng Q, Zhou P, Ou X, Meng Q, He T,Luo J. Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells. Int J Mol Med. 2015 Jun;35(6):1641-1650.(通讯作者)
19.Liu Y, Wang W, Xu J, Li L, Dong Q, Shi Q, Zuo G, Zhou L, Weng Y, Tang M, He T,Luo J. Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/β-catenin signaling. Oncol Rep. 2013;30(4):1723-1730.(通讯作者)
20.Song T, Wang W, Xu J, Zhao D, Dong Q, Li L, Yang X, Duan X, Liang Y, Xiao Y, Wang J, He J, Tang M, Wang J,Luo J.Fibroblast growth factor 2 inhibits bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells by repressing Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2. Int J Biochem Cell Biol. 2013;45(8):1639-1646.(通讯作者)
21.Zhao YF, Xu J, Wang WJ, Wang J, He JW, Li L, Dong Q, Xiao Y, Duan XL, Yang X, Liang YW, Song T, Tang M, Zhao D,Luo JY.Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep. 2013;46(8):422-427.(通讯作者)
22.Xu DJ, Zhao YZ, Wang J, He JW, Weng YG,Luo JY. Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells. BMB Rep. 2012;45(4):247-252.(通讯作者)
23.Luo J, Tang M, Huang J, He BC, Gao JL, Chen L, Zuo GW, Zhang W, Luo Q, Shi Q, Zhang BQ, Bi Y, Luo X, Jiang W, Su Y, Shen J, Kim SH, Huang E, Gao Y, Zhou JZ, Yang K, Luu HH, Pan X, Haydon RC, Deng ZL, He TC. TGFβ/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. J Biol Chem. 2010;285(38):29588-29598.(第一作者)
24.Wu N, Zhao Y, Yin Y, Zhang Y,Luo J. Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenicdifferentiation of C3H10T1/2 mesenchymal stem cells. Acta Biochimica et Biophysica Sinica. 2010;42(10):699-708(通讯作者)
25.Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW, Vogelstein B, He TC. A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nature Protocols. 2007; 2(5): 1236-1247(第一作者)
26.Luo J, Chen J, Deng ZL, Luo X, Song WX, Sharff KA, Tang N, Haydon RC, Luu HH, He TC. Wnt signaling and human diseases: what are the therapeutic implications? Laboratory Investigation. 2007;87(2): 97-103(第一作者)
参编教材与专著
参编:实用检验医学(第二版),人民卫生出版社,2013年出版,p444-453,2万字
参编:临床检验病原生物学实验指导,高等教育出版社,2006年出版,2万字
专利
“淋病奈瑟菌荧光定量PCR检测试剂盒”(排名第二)获得国家发明专利(专利号:ZL200510020234.3)