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专职教师

丁世家 二级教授,博士生导师

2019年11月08日 11:42  点击:[]

 

 

丁世家,男,1963年出生,医学博士,二级教授,博士生导师。第三批重庆市学术技术带头人。

E-mail:dingshijia@163.com / dingshijia@cqmu.edu.cn

教育/培训经历:

毕业于重庆医科大学医学检验系,获医学博士学位

毕业于南京大学化学系,获理学硕士学位

毕业于四川大学化学系,获理学学士学位

曾先后前往荷兰Utrecht University药学院、美国USC化学系、日本Kumamoto University药学院从事访问研究

学术兼职:

重庆市医学检验技术学术技术带头人

临床检验诊断学教育部重点实验室生物分析化学学科带头人

重庆市分析测试学会医学检测专委会秘书长

重庆市刑事侦查技术工程研究中心法医毒物分析主任

重庆市法医学会毒物分析主任委员

重庆市司法鉴定协会法医毒化鉴定委员会主任委员

科研方向:

分子诊断与生物分析化学

课题组主要将临床医学检验技术与分子生物学、生物分析化学等学科交叉融合,围绕疾病标志物检测新原理、新技术,在分子诊断、生物传感、表面等离子共振及成像等方面开展了一系列创新研究。具体包括:

➢分子诊断与液体活检

➢纳米自组装技术与生物传感

➢表面等离子共振及成像技术研发与临床应用

➢新型纳米材料合成与生物成像应用

学术成果:

➢研究成果“疾病生物标志物高灵敏检测新方法研究”获2017年度重庆市科学技术奖(自然科学奖)一等奖(排名第一)

➢主持承担国家自然科学基金面上项目、科技部重大专项子课题、重庆市科委重点项目、重庆市教委优秀成果转化重点项目等科研课题15项

➢已在ACS Appl Mater Interfaces,Anal.Chem.,Biosens. Bioelectron等国际著名期刊上发表高水平SCI论文90余篇,其中IF>5.0的论文43篇

➢获国家发明专利授权9项

➢研发出国内首台具有完全自主知识产权的表面等离子共振成像生化分析仪

➢已招生和培养博士后2名,博士13名,硕士39名

近三年发表的代表性论文:

2019年:

1. Xintong Bian, Bin Guo, Min Zhao, Daobin Han, Wei Cheng , Fangzhou Song, Shijia Ding*, An Enzyme-Free “ON-OFF” Electrochemiluminescence Biosensor for Ultrasensitive Detection of PML/RARα based on Target-Switched DNA Nanotweezer,ACS Applied Materials& Interfaces, 2019, 11 (4): 3715-3721.(IF=8.456)

2. Min Zhao, Lijuan Bai, Wei Cheng, Xiaolei Duan, Haiping Wu, Shijia Ding*, Monolayer rubrene functionalized graphene-based eletrochemiluminscence biosensor for serum cystatin C detection with immunorecognition induced 3D DNA machine,Biosensors and Bioelectronics, 2019, 127: 126-134.(IF=9.518)

3. Xiaoyan Zhou, Yujian Li, Haiping Wu, Wei Huang, Huangxian Ju, Shijia Ding*, An amperometric immunosensor for sensitive detection of circulating tumor cells using a tyramide signal amplification-based signal enhancement system,Biosensors and Bioelectronics, 2019, 130: 88-94.(IF=9.518)

4. Jia Li, Yu Xiang, Lutan Zhang, Lizhen Huang, Jie Teng, Shijia Ding, Wei Cheng, Dynamic DNA self-assembly activated hemin-mimetic enzyme system for versatile fluorescent biosensing,Sensors and Actuators B: Chemical, 2019, 288: 757-762. (IF=6.393)

5. Huidan Sun, Shaoyan Wu, Xiaoyan Zhou, Min Zhao, Haiping Wu, Rong Luo*, Shijia Ding*, Electrochemical sandwich immunoassay for insulin detection based on the use of gold nanoparticle-modified MoS2nanosheets and the hybridization chain reaction,Microchimica Acta, 2019, 186: 6.(IF=5.479)

6. Daobin Han, Yurong Yan, Jianmin Wang, Min Zhao, Xiaolei Duan, Liangsheng Kong, Haiping Wu, Wei Cheng, Xun Min*, Shijia Ding*, An Enzyme-Free Electrochemiluminesce Aptasensor for the Rapid Detection of Staphylococcus Aureus by the Quenching Effect of MoS2-PtNPs-Vancomycin to S2O82/O2System,Sensors and Actuators B: Chemical, 2019, 288: 586-593.(IF=6.393)

7. Lu Fan, Yurong Yan, Bin Guo, Min Zhao, Jia Li, Xintong Bian, Haiping Wu, Wei Cheng*, Shijia Ding*, Trimetallic hybrid nanodendrites and magnetic nanocomposites-based electrochemical immunosensor for ultrasensitive detection of serum human epididymis protein 4,Sensors and Actuators B: Chemical, 2019, 296: 126697. (IF=6.393)

2018年:

1. Bin Guo,Bo Wen,Wei Cheng,Xiaoyan Zhou,Xiaolei Duan,Min Zhao,Qianfeng Xia, Shijia Ding*. An enzyme-free and label-free surface plasmon resonance biosensor for ultrasensitive detection of fusion gene based on DNA self-assembly hydrogel with streptavidin encapsulation.Biosensors & Bioelectronics, 2018, 112:120-126.(IF=8.173)

2. Xiaoyan Zhou, Jianhua Pan, Yongneng Ma, Xiujuan Peng, Haiping Wu, Qin Zhou, Shijia Ding*, Huangxian Ju*. An ultrasensitive fluorescence sensing strategy for detection and in situ imaging of chronic myeloid leukemia-related BCR-ABL1 mRNA.Sensors & Actuators: B. Chemical, 2018, 273:1456-1462.(IF=5.667)

3. Dongmei Huang, Xinmin Li, Bo Shen, Jia Li, Xiaojuan Ding, Xiaoyan Zhou, Bin Guo, Wei Cheng, Shijia Ding*. Enzyme-free dual-amplification strategy for the rapid, single-step detection of nucleic acids based on hybridization chain reaction-initiated entropy-driven circuit reaction.Sensors and Actuators B: Chemical, 2018, 273:393-399.(IF=5.667)

4. Chenlan Shen, Bo Shen, Fei Mo, Xiaoyan Zhou, Xiaolei Duan, Xiaotong Wei, Jia Li, Yu Duan, Wei Cheng, Shijia Ding*. High-sensitive colorimetric biosensing of PIK3CA gene mutation based on mismatched ligation-triggered cascade strand displacement amplification.Sensors &Actuators: B. Chemical, 2018, 273:377-383.(IF=5.667)

5. Dandan Li, Fei Mo, Jiangling Wu, Yong Huang, Huihao Zhou, Shijia Ding*, Weixian Chen*. A multifunctional DNA nano-scorpion for highly efficient targeted delivery of mRNA therapeutics.Scientific Reports, 2018, 8:10196.(IF=4.122)

6. Xiaotong Wei, Xiaolei Duan, XiaoyanZhou, Jiangling Wu, Hongbing Xu, Xun Min, ShijiaDing*. A highly sensitive SPRi biosensing strategy for simultaneous detection of multiplex miRNAs based on strand displacement amplification and AuNP signal enhancement.Analyst, 2018, 143:3134.(IF=3.864)

7. Haiping Wu, Xiaoyan Zhou, Wei Cheng, Taixian Yuan, Min Zhao, Xiaolei Duan, Shijia Ding*. A simple fluorescence biosensing strategy for ultrasensitive detection of BCR-ABL1 fusion gene based on DNA machine and multiple primers-like rolling circle amplification.Analyst, 143:4974-4980.(IF=3.864)

8. Yu Duan, Taixian Yuan, Yongjie Xu, Min Zhao, Bin Guo, Wei Cheng, Shijia Ding*. Detection of BCR/ABL fusion gene based on MNAzyme-mediated target-cycling and ssDNA-assisted cascade hybridization reaction.Electroanalysis, 2018, 10:2427-2433.(IF=2.851)

2017年:

1. Xiaojuan Ding, Wei Cheng, Yujian Li, Jiangling Wu, Xinmin Li, Quan Cheng, Shijia Ding*. An enzyme-free surface plasmon resonance biosensing strategy for detection of DNA and small molecule based on nonlinear hybridization chain reaction.Biosensors & Bioelectronics, 2017, 87: 345-351.(IF=8.173)

2. Xiaoyan Zhou, Min Zhao, Xiaolei Duan, Bin Guo, Wei Cheng, Shijia Ding*, Huangxian Ju*. Collapse of DNA Tetrahedron Nanostructure for “Off−On” Fluorescence Detection of DNA Methyl transferase Activity,ACS Applied Materials & Interfaces, 2017, 9 (46):40087-40093.(IF=8.097)

3. Xiaojuan Ding, Yihua Wang, Wei Cheng, Fei Mo, Ye Sang, Lulu Xu, Shijia Ding*. Aptamer based electrochemical adenosine triphosphate assay based on a target-induced dendritic DNA nanoassembly.Microchimica Acta, 2017,184 (2):431-438.(IF=5.705)

4. Ye Sang, Yongjie Xu, Wei Cheng, Xinmin Li, Jiangling Wu, Shijia Ding*. Colorimetric and visual determination of microRNA via cycling signal amplification using T7 exonuclease.Microchimica Acta, 2017, 184 (7): 2465-2471.(IF=5.705)

5. Bin Guo, Wei Cheng, Yongjie Xu, Xiaoyan Zhou, Xinmin Li, Xiaojuan Ding, Shijia Ding*. A simple surface plasmon resonance biosensor for detection of PML/RARα based on heterogeneous fusion gene-triggered nonlinear hybridization chain reaction.Scientific Reports, 2017, 7(1):14037.(IF=4.122)

6. Yueli Xing, Xinmin Li, Taixian Yuan, Wei Cheng, Dandan Li, Tianxiao Yu, Xiaojuan Ding, Shijia Ding*. Engineering high-performance hairpin stacking circuits for logic gate operation and highly sensitive biosensing assay of microRNA.Analyst, 2017, 124(24):4834-4842.(IF=3.864)

7. Yueping Xu, Yongjie Xu, Zhong Zuo, Xiaoyan Zhou, Bin Guo, Ye Sang, Shijia Ding*. Triggered hairpin switch and in situ nonlinear hybridization chain reaction enabling label-free electrochemiluminescent detection of BCR/ABL fusion gene.Journal of Electroanalytical Chemistry, 2017, 801:192-197.(IF=3.235)

8. Rong Hu, Ganglin Wang, Rui Yuan, Yongjie Xu, Tianxiao Yu, Liang Zhong, Qin Zhou*, Shijia Ding*. An electrochemical biosensor for highly sensitive detection of microRNA-377 based on strand displacement amplification coupled with three-way junction.Journal of Electroanalytical Chemistry, 2017, 789:160-166.(IF=3.235)

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