■ 基本信息

易钢，男，1964年4月出生，医学硕士，教授，硕士生导师，重庆医科大学第八、九、十届教学督导专家组成员，参与专著和教材编写七部，发表研究论文五十余篇。

■ 联系方式

重庆医科大学检验医学院、临床检验诊断学教育部重点实验室，400016

电子邮箱：yigang666@cqmu.edu.cn

■ 学习与工作经历

1982.09-1986.07 重庆大学，应用化学，理学学士

1986.07-1993.05 重庆医科大学医学检验系，助教

1993.05-2007.09 重庆医科大学医学检验系，讲师

2007.07-2017.07 重庆医科大学检验医学院，副教授

2017.07-2024.05 重庆医科大学检验医学院，教授

2005.05-2024.05 临床检验诊断学教育部重点实验室

■ 研究方向

课题组主要融合生物分析化学、医学检验技术、分子生物学等学科，围绕疾病诊断标志物检测新方法、新技术等方面开展系列创新研究。主要包括：

1. 化学发光分析体系与应用研究方向

2. 电化学生物传感和纳米技术方向

■ 科研项目

1. 2020年度市教委科学技术研究计划重点课题，KJZD-K202000404，“基于DNA四面体修饰的树枝状杂交链信号放大反应超灵敏检测DNA甲基化”5万，2020.10-2023.10，已结题，主持。

2. 重庆市渝中区科委基础研究与前沿探索项目，20180127，“基于3-D DNA walker和超分支滚环扩增（HRCA）的通用型检测新方法的研究”，2018.10-2021.10，已结题，主持。

■ 学术论著

1. Zixin Zhao, Zuowei Xie, Siyi Chen, Min Chen, Xinyu Wang, Gang Yi*. A novel biosensor based on tetrahedral DNA nanostructure and terminal deoxynucleotidyl transferase-assisted amplification strategy for fluorescence analysis of uracil-DNA glycosylase activity. Analytica Chimica Acta, 2023;1271（2023）341432.（通讯作者，2023，IF=6.20）

2. Siyi Chen, Zuowei Xie, Wenxiu Zhang, Shuhui Zhao, Zixin Zhao, Xinyu Wang, Yuqi Huang, Gang Yi*. Double-wings switch nanodevice-mediated primer exchange reaction for the activity analysis of cancer biomarker FEN1. Analytica Chimica Acta,2023;1238(2023)340653.（通讯作者，2023，IF=6.911）

3. Zuowei Xie, Siyi Chen, Wenxiu Zhang, Shuhui Zhao, Zixin Zhao, Xingyu Wang, Yuqi Huang, Gang Yi*. A novel fluorescence amplification strategy combining cascade primer exchange reaction with CRISPR/Cas12a system for ultrasensitive detection of RNase H activity. Biosensors and Bioelectronics, 2022;206:114-135.（通讯作者，2022，IF=12.545）

4. Zuowei Xie1, Xingyu Wang1, Siyi Chen, Zixin Zhao, Shuhui Zhao, Wenxiu Zhang, Lijuan Luo, Gang Yi*. Construction of a simple, localized and homogeneous fluorescence detection platform for T4 PNK activity based on tetrahedral DNA nanostructure-mediated primer exchange reaction. Microchemical Journal, 2022;183:107989（通讯作者，2022，IF=5.304）

5. Wenxiu Zhang, Shuhui Zhao, Zuowei Xie, Siyi Chen, Yuqi Huang, Zixin Zhao，Gang Yi. The fluorescence amplification strategy based on 3D DNA walker and CRISPRCas-12a for the rapid detection of BRAF V600E. Analytical Sciences. 2022;38:1057-1066（通讯作者，2022，IF=2.081）

6. Yuqi Huang, Wenxiu Zhang, Shuhui Zhao, Zuowei Xie, Siyi Chen, Gang Yi. Ultra-sensitive detection of DNA N6-adenine methyltransferase based on a 3D tetrahedral fluorescence scaffold assisted by symmetrical double-ring dumbbells.Analytica Chimica Acta. 2021;11:1-8;（通讯作者，2021，IF=6.558）

7. Changjing Yuan, Jie Fang, Qiuyue Duan, Qi Yan, Jing Guo, Taixian Yuan, Gang Yi*. Two-layer three-dimensional DNA walker with highly integrated entropy-driven and enzyme-powered reactions for HIV detection. Biosensors and Bioelectronics, 2019;133:243-249（通讯作者，2019，IF=10.257）

8. Jing Guo, Changjing Yuan, Qi Yan, Qiuyue Duan, Xiaolu Li, Gang Yi*. An electrochemical biosensor for microRNA-196a detection based on cyclic enzymatic signal amplification and template-free DNA extension reaction with the adsorption of methylene blue. Biosensors and Bioelectronics, 2018;105: 103-108（通讯作者，2018，IF=8.173）

9. Xiaolu Li, Jing Guo, Qian Zhai, Jing Xia, Gang Yi*. Ultrasensitive electrochemical biosensor for specific detection of DNA based on molecular beacon mediated circular strand displacement Polymerization and hyperbranched rolling circle amplification. Analytica Chimica Acta, 2016;934, 52-58（通讯作者，2016，IF=4.712）

10. Qian Zhai, Yun He, Xiaolu Li, Jing Guo, Shengqian Li, Gang Yi*. A simple and ultrasensitive electrochemical biosensor for detection of microRNA based on hybridization chain reaction amplification. Journal of Electroanalytical Chemisty, 2015;10.010,758, 20-25（通讯作者，2015，IF=2.822）

11. Hu Fu, Chuang Ge, Wei Cheng, Caihui Luo, Decai Zhang, Li Yan, Yun He, Gang Yi*. A Hairpin Electrochemical Aptasensor for Sensitive and Specific Detection of Thrombin Based on Homogenous Target Recognition. Electroanalysis, 2013;3:1223-1229（通讯作者，2013，IF=2.88）

■ 专利授权

获得授权国内发明专利3项