■ 基本信息

赵成珠，博士，博士后，副教授

■ 联系方式

电子邮箱：chengzhu.zhao@cqmu.edu.cn

■ 学习与工作经历

2024-至今  重庆医科大学，检验医学院，副教授

2021-2024  重庆医科大学，生命科学研究院，副教授

2016-2021  京都大学 iPS 细胞研究所，临床应用研究部门，博士后

2014-2016  京都大学药学研究科，特定研究员

2011-2016  京都大学药学研究科，生命药科学， 博士

2009-2011  冈山大学药学研究科，药科学，硕士

■ 研究方向

1. 开发诱导性多能干细胞（induced pluripotent stem cell, iPSC）向神经嵴和中胚层方向（如骨、软骨、肌肉、肌腱/韧带及末梢神经等）分化与纯化的系统，以及将现有的分化方法转化为可应用于临床的无血清、无动物来源的细胞制备体系；

2. 结合3D生物打印、生物支架和器官芯片等组织工程技术构建类器官，并应用于疾病模型构建、药物筛选和再生医学研究；

3. 基于罕见病患者来源的iPS细胞构建体外疾病模型，并在此基础上进行机制研究和药物开发。

■ 科研项目

1. 国家自然科学基金青年项目, BMP-9介导的MSC异常增殖引起的急性发作在进行性骨化性纤维发育不良中的作用与机制研究，2023-01至 2025-12；

2. 2023年8月，基于iPSC技术的人工肌腱/韧带构建及再生修复研究，重庆市留学人员回国创新项目；

3. 2021年9月，重庆医科大学引进人才启动金；

4. Japan Society for the Promotion of Science (JSPS), Grants-in-Aid for Scientific Research (C)，ACVR1変異によるFOP細胞増殖亢進の原因分子の同定と解析 (识别并解析通过作用于变异ACVR1介导FOP细胞增殖亢进的分子), 2021-04至 2023-03（日本）；

5. Japan Society for the Promotion of Science (JSPS), Grants-in-Aid for Early-Career Scientists, Mechanism elucidation and drug development of early-stage FOP respond to TGF-β signaling using patient-derived iPSCs, 2019-04 至 2021-03（日本）；

6. Japan Society for the Promotion of Science (JSPS), Grants-in-Aid for Early-Career Scientists (B), Drug development of fibrodysplasia ossificans progressiva through constitutive activation of FOP-ACVR1, 2017-04 至 2019-03（日本）。

■ 近五年主要学术论著

1. Guo Q, Chen J, Bu Q, Zhang J, Ruan M, Chen X, Zhao M, Tu X† and Zhao C†. Establishing stable and highly osteogenic hiPSC-derived MSCs for 3D-printed bone graft through microenvironment modulation by CHIR99021-treated osteocytes. Materials Today Bio. In press. DOI: 10.1016/j.mtbio.2024.101111, Epub 2024/05/31. (†: corresponding authors)

2. Zujur D, Al-Akashi Z, Nakamura A, Zhao C, Takahashi K, Aritomi S, Theoputra W, Kamiya D, Nakayama K, Ikeya M. Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair. Front Cell Dev Biol. 2023 May 10;11:1140717.

3. Mizuno K, Ohnishi H, Yoshimatsu M, Zhao C, Hayashi Y, Kuwata F, Kaba S, Okuyama H, Kawai Y, Hiwatashi N, Kishimoto Y, Sakamoto T, Ikeya M, Omori K. Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells. Cell Transplant. 2023 Jan-Dec; 32:9636897231178460.

4. Zhao C, Inada Y, Sekiguchi K, Hino K, Nishio M, et al. Myelin protein zero (P0)- and Wnt1-Cre marked muscle resident neural crest-derived mesenchymal progenitor cells give rise to heterotopic ossification in mouse models.Genes Dis. ISSN 2352-3042, Epub 2022/09/19.

5. Kamiya D, Takenaka-Ninagawa N, Motoike S, Kajiya M, Akaboshi T, Zhao C, et al. Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage. NPJ Regen. Med. Sep 15 2022;7(1):1-17. Epub 2022/08/08.

6. Nakajima T, Nakahata A, Yamada N, Yoshizawa K, Kato TM, Iwasaki M, Zhao C, et al. Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture. Nat Commun. Aug 18 2021;12(1):5012. Epub 2021/08/20.

7. Yoshimatsu M, Ohnishi H, Zhao C, Hayashi Y, Kuwata F, Kaba S, et al. In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells. Stem Cell Res. Apr 2021;52:102233. Epub 2021/02/20.

8. Mitsuzawa S*, Zhao C*, Ikeguchi R, Aoyama T, Kamiya D, Ando M, et al. Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Sci Rep. Jul 21 2020;10(1):12034. Epub 2020/07/23. (*: Co-first authors)

9. Mitsuzawa S, Ikeguchi R, Aoyama T, Ando M, Takeuchi H, Yurie H, Oda H, Noguchi T, Ohta S, Zhao C, et al. Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model. Microsurgery. Nov 2019;39(8):737-47. Epub 2019/09/01.

10. Hino K*, Zhao C*, Horigome K, Nishio M, Okanishi Y, Nagata S, et al. An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva. Stem Cell Reports. 2018;11(5):1106-19. (*: Co-first authors)

■ 会议报告

1. iPS细胞技术在罕见病研究中的应用，中西医结合基础与应用学术年会，2022年12月

2. ER counter-ion channel TRIC-B regulates collagen production and bone mineralization. The 94th Annual Meeting of the Physiological Society of Japan. March, 2017 (Hamamatsu, Japan)

3. Drug development of development of fibrodysplasia ossificans progressive (FOP) focused on constitutve activation of FOP-ACVR1. The 93th Annual Meeting of Japanese Pharmacological Society. March, 2019 (Osaka, Japan)

4. Indirect mTOR Inhibition Attenuates Fibrodysplasia Ossificans Progressiva (FOP) Identified by Using Patient-Derived iPSCs. ISSCR 2019 Annual Meeting. June, 2019 (Los Angeles, CA, USA).

5. Compromised collagen production in Tric-b-knockout osteoblast. Biophysical Society, 60th Annual Meeting. February, 2016 (Los Angeles, CA, USA).

6. Impaired bone formation in Tric-b-knockout mice. Biophysical Society, 58th Annual Meeting. February, 2014 (San Francisco, CA, USA).

■ 会议报告

2023年6月，基于成骨微环境的3D生物打印智能制造技术项目，重庆市首届卓越工程师大赛，十佳成果转化奖