智慧 + 坚韧不拔
WELCOME
当前位置: 首页>>原首页>>师资队伍>>专职教师>>正文
专职教师

尹一兵 二级教授,博士生导师

2018年11月02日 10:42  点击:[]

 

尹一兵,男,1956年出生,重庆人,二级教授,博士生导师。

临床检验诊断学国家重点学科带头人,重庆市有突出贡献中青年专家,第二批重庆市学术技术带头人,重庆市教学名师。教育部医学技术类教学指导委员会副主任委员,全国高等学校医学检验技术专业教材编审委员会主任委员(人民卫生出版社),中华医学会检验分会委员,重庆市医学会检验专委会名誉主任委员,重庆市分析测试学会副理事长。2005年2016年任重庆医科大学检验医学院院长、临床检验诊断学教育部重点实验室主任,2012年2017年兼任重庆医科大学附属儿童医院临床检验中心主任。

工作学习简历

1982年毕业于重庆医学院医学系(77级);

1982.2-1984.3,重庆市第三人民医院住院医师;

1984.3-至今,重庆医科大学工作;

其中:

1985.9-1989.7,重庆医科大学攻读临床检验诊断学专业研究生,获医学硕士学位;

1991.12-1994.1,美国纽约Rockefeller大学分子传染病实验室助理研究员;

1994.1-1999.3,重庆医科大学医学检验系临床生化教研室副主任、副教授、硕士生导师;

1999.3-2005.2,重庆医科大学医学检验系副主任、副教授(2003.10 晋升教授)、硕士生导师(2004.5 聘任博士生导师);

2005.2-2011.5,重庆医科大学医学检验系主任、教授(2009年评为二级教授)、博士生导师;

2011.5-2016.3,重庆医科大学检验医学院院长、教授、博士生导师;

2016.3-至今,重庆医科大学检验医学院教授、博士生导师。

教学科研工作

承担了本科、研究生的临床生物化学、分子诊断学、检验与临床等课程,指导培养了多名青年师资成为教学科研骨干。主持了教育部高校教学研究中心“21世纪中国高等学校医学检验专业课程体系与教学内容的创新与实践”等教改课题,主、参编专著教材20多部,其中主编的《分子诊断学》列入“十一五”国家级规划教材,主编的《临床生物化学检验技术》列入“十二五”国家级规划教材,讲授的《临床生物化学》课程先后列入国家精品课程和国家级精品资源共享课。先后获得国家级教学成果奖2项,省部级教学成果奖5项,其中“面向社会需求,建立医学检验专业复合型人才培养体系”获2009年国家级教学成果二等奖(第1),“医学检验特色专业的建设与实践”获2009年重庆市教学成果一等奖(第1)。先后主持了国家自然科学基金课题8项,及教育部、重庆市课题多项,发表科研论文100余篇,其中通讯(及共同)作者发表SCI收录论文38篇,获重庆市自然科学二等奖1项(排名第一),获国家发明专利授权3项(排名第一)。

主要研究领域:分子微生物学。

一、代表性研究论文

1. Progranulin Plays a Central Role in Host Defense During Sepsis by Promoting Macrophage Recruitment,AM J RESP CRIT CARE,2016 Nov 15;194(10):1219-1232,IF=13.204,

2. Activation of IL‐27 signalling promotes development of postinfluenza pneumococcal pneumonia,EMBO MOL MED,2014 Jan 1;6(1):120-140,IF=8.665,

3. Ultrasensitive scanometric strategy for detection of matrix metalloproteinases using a histidine tagged peptide–Au nanoparticle probe,CHEM COMMUN,2011 Mar 14;47(10):2877-9,IF=6.169,

4. Interleukin 4 Deficiency Reverses Development of Secondary Pseudomonas aeruginosa Pneumonia During Sepsis-Associated Immunosuppression,J INFECT DIS,2015 May 15;211(10):1616-27,IF=5.997,

5. Cascade signal amplification strategy for subattomolar protein detection by rolling circle amplification and quantum dots tagging,ANAL CHEM,2010 Apr 15;82(8):3337-3342,IF=5.874,

6. The Role Played by Interleukin-10 in Cytokine and Chemokine Dysregulation during Secondary Pneumococcal Pneumonia after Influenza,J INFECT DIS,2009 May 15;199(10):1555-1556 (LETTER),IF=5.865,

7. A facile scanometric strategy for ultrasensitive detection of protein using aptamer-initiated rolling circle amplificationw,CHEM COMMUN,2010 Sep 28;46(36):6720-6722,IF=5.787,

8. DNA transducer-triggered signal switch for visual colorimetric bioanalysis,SCI REP-UK,2015 Jun 10;5:11190.,IF=5.578,

9. CpsR, a GntR family regulator, transcriptionally regulates capsular polysaccharide biosynthesis and governs bacterial virulence in Streptococcus pneumoniae.,SCI REP-UK,2016 Jul 8;6:29255.,IF=4.259,

10. Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice,INFECT IMMUN,2011 Feb; 79(2):867-78,IF=4.165,

11. ComE, an Essential Response Regulator, Negatively Regulates the Expression of the Capsular Polysaccharide Locus and Attenuates the Bacterial Virulence in Streptococcus pneumoniae.,FRONT MICROBIOL,2017 Mar 7;8:277.,IF=4.165,

12. Immunization with a Combination of Three Pneumococcal Proteins Confers Additive and Broad Protection against Streptococcus pneumoniae Infections in Mice,INFECT IMMUN,2010 Mar;78(3):1276-1283,IF=4.098,

13. IL-17B is elevated in patients with pneumonia and mediates IL-8 production in bronchial epithelial cells,CLIN IMMUNOL,2017 Feb;175:91-98.,IF=3.99,

14. Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation,IMMUNOLOGY,2015 Jun;145(2):279-87,IF=3.795,

15. c-Jun N-terminal kinase and Akt signaling pathways regulating tumour necrosis factor-α-induced IL-32 expression in human lung fibroblasts: implications in airway inflammation,IMMUNOLOGY,2015 Feb;144(2):282-290,IF=3.795,

16. Mucosal Immunization with Recombinant Fusion Protein DnaJ-ΔA146Ply Enhances Cross-Protective Immunity against Streptococcus pneumoniae Infection in Mice via Interleukin 17A,INFECT IMMUN,2014 Apr;82(4):1666-75,IF=3.731,

17. Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma,J CANCER,2017;8(8):1362-1370,IF=2.916,

18. Mucosal and systemic immunization with a novel attenuated pneumococcal vaccine candidate confer serotype independent protection against Streptococcus pneumoniae in mice,VACCINE,2014 Jul 16;32(33):4179-4188,IF=3.624,

19. CD4+ T lymphocytes mediated protection against invasive pneumococcal infection induced by mucosal immunization with ClpP and CbpA,VACCINE,2009 May 11;27(21):2838-2844,IF=3.616,

20. Expression of Toll-Like Receptor 2 by Dendritic Cells Is Essential for the DnaJ-ΔA146Ply-Mediated Th1 Immune Response against Streptococcus pneumoniae.,INFECT IMMUN,2018 Feb 20;86(3). pii: e00651-17.,IF=3.603,

21. Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae,VACCINE,2011 Feb;29(9):1736-44,IF=3.572,

22. Structural basis of the novel S. pneumoniae virulence factor, GHIP, a glycosyl hydrolase 25 participating in host-cell invasion.,PLOS ONE,2013 Jul 16;8(7):e68647,IF=3.534,

23. Protection against pneumococcal infection elicited by immunization with glutamyl tRNA synthetase, polyamine transport protein D and sortase A,VACCINE,2012 May 21;30(24):3624-3633,3.492,

24. Enhanced Protection against Pneumococcal Infection Elicited By Immunization with the Combination of PspA,PspC,and ClpP,VACCINE,2007 Jun 28;25(27):4996-5005,IF=3.377,

25. Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection,CLIN EXP IMMUNOL,2009 Apr;156(1):52-60,IF=3.009,

26. PCA3 gene expression in prostate cancer tissue in a Chinese population: quantification by real-time FQ-RT-PCR based on exon 3 of PCA3,EXP MOL PATHOL,2010 Aug;89(1):58-62,IF=2.986,

27. Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK),BMC MICROBIOL,2009 Jun 27;9:129,IF=2.89,

28. A Novel Protein, RafX, Is Important for Common Cell Wall Polysaccharide Biosynthesis in Streptococcus pneumoniae: Implications for Bacterial Virulence,J BACTERIOL,2014 Sep 15;196(18):3324-34,IF=2.808,

29. Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice,MICROBES INFECT,2008 Nov-Dec;10(14-15):1536-1542,IF=2.801,

30. Facile Fabrication of a Gold Nanocluster-Based Membrane for the Detection of Hydrogen Peroxide.,SENSORS-BASEL,2016 Jul 20;16(7). pii: E1124.,IF=2.667,

31. Molecular mechanisms of the secretion of cytokines and chemokines from human monocytes activated by pneumococcal surface protein A (PspA): Roles of mitogenactivated protein kinases and NF-kappaB,MICROB PATHOGENESIS,2010 Jun;48(6):220-9,IF=2,

32. Real-time quantitative assay of HCV RNA using the duplex scorpion primer,ARCH VIROL,2007 Feb;152(2):431-440,IF=1.839,

33. SCCmec-associated psm-mec mRNA promotes Staphylococcus epidermidis biofilm formation,ANTON LEEUW INT J G,2016 Oct;109(10):1403-1415.,IF=1.795,

34. Contribution of ClpE to virulence of Streptococcus pneumoniae,CAN J MICROBIOL,2009 Oct;55(10):1187-1194,IF=1.262,

35. Identification of Streptococcus pneumoniae genes specifically induced in mouse lung tissues,CAN J MICROBIOL,2008 Jan;54(1):58-65,IF=1.102,

36. The Effect of Transformation on the Virulence of Streptococcus pneumoniae,J MICROBIOL,2005 Aug;43(4):337-344,IF=0.967,

37. Purification, crystallization and preliminary X-ray studies of the putative lysozyme SP0987 from Streptococcus pneumoniae,ACTA CRYSTALLOGR F,2010 Mar 1;66(Pt 3):286-288,IF=0.563,

38. In vivo characterization of Streptococcus pneumoniae genes involved in the pathogenesis of meningitis by differential fluorescence induction,SAUDI MED J,2010 Apr;31(4):382-388,IF=0.56,

二、教材著作编写(主编、副主编)

1.《检验医学高级教程》第2版,科学出版社,2017.4,主编(2/3)

2.《临床生物化学检验技术》“十二五”普通高等教育本科国家级规划教材,人民卫生出版社,2015.3,主编(1/2)

3.《实验诊断学》“十二五”普通高等教育本科国家级规划教材,人民卫生出版社,2015.5,副主编(1/4)

4.《全国临床检验操作规程》第4版,人民卫生出版社,2015.4,专业主编(1/2)

5.《检验医学高级教程》下册,人民卫生出版社,2010.6,主编(2/3)

6.《实用检验医学》上下册,人民卫生出版社,2009.5,副主编(4/21)

7.《分子诊断学》普通高等教育“十一五”国家级规划教材,高等教育出版社,2007.1,主编(1)

8.《临床蛋白质组学》“十一五”国家重点图书,科学出版社,2008.4,主编(2/2)

9.《分子诊断学》第2版,中国医药科技出版社,2010.2,主编(2/2)

10.《分子诊断学》,中国医药科技出版社,2004.8,主编(2/2)

三、发明专利(第一发明人)

1. 肺炎链球菌溶血素突变体及其作为粘膜免疫佐剂的作用,国家发明专利,ZL201410180889.6,授权日期2016.3

2. 肺炎链球菌减毒活疫苗,国家发明专利,ZL200910104370.7,授权日期2011.11

3. 淋病奈瑟菌荧光定量PCR检测试剂盒,国家发明专利,ZL200510020234.3,授权日期2008.9

关闭